リハビリテーション学科 理学療法学専攻 Physical Therapy

関西福祉科学大学 HOME  >  学部・学科・大学院  >  保健医療学部  >  リハビリテーション学科 理学療法学専攻  >  教員紹介  >  下村 和範

下村 和範

リハビリテーション学科 理学療法学専攻

教授 下村 和範 しもむら かずのり
専門分野

整形外科、スポーツ整形外科、再生医療

附属整形外科リハビリ診療所で整形外科、スポーツ整形外科の診療を行なっております。
分かりやすい説明を心がけ、誠意を持って診療に当たります。膝関節スポーツ外傷(靭帯損傷、半月板・軟骨損傷など)、変形性膝関節症に対しては、近隣の病院と連携して手術を行なっております。
また運動器組織再生(軟骨、半月板など)の研究に取り組んでおり、国内外問わず学術集会での発表や国際論文の発表を積極的に行なっております。
担当科目 救急医療、整形外科学

MESSAGE

大学生活を通じて楽しいことも辛いことも多く経験すると思います。その一つ一つが今後の糧となります。夢を大きく持って、チャレンジを恐れず、将来なりたい自分に向かって頑張って下さい。充実した大学生活になることを祈念致します。

学位 医学博士(大阪大学大学院 医学系研究科 2012年3月)
最終学歴 大阪市立大学 医学部(2003年3月修了)
教育・研究実績
・英語論文
1. Shimomura K, Ando W, Tateishi K, Nansai R, Fujie H, Hart DA, Kohda H, Kita K, Kanamoto T, Mae T, Nakata K, Shino K, Yoshikawa H, Nakamura N. The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model. Biomaterials. 2010 Nov; 31(31): 8004-11. 
2. Nansai R, Suzuki T, Shimomura K, Ando W, Nakamura N, Fujie H. Surface morphology and stiffness of cartilage-like tissue repaired with a scaffold-free tissue engineered construct. J Biomech Sci Eng. 2011; 6(1): 40-48.
3. Ando W, Fujie H, Moriguchi Y, Nansai R, Shimomura K, Hart DA, Yoshikawa H, Nakamura N. Detection of abnormalities in the superficial zone of cartilage repaired using a tissue engineered construct derived from synovial stem cells. European Cells and Materials. 2012 Sep 28; 24: 292-307. 
4. Oya K, Aoki S, Shimomura K, Sugita N, Suzuki K, Nakamura N, Fujie H. Morphological observations of mesenchymal stem cell adhesion to a nanoperiodic-structured titanium surface patterned using femtosecond laser processing. Jpn J Appl Phys. 2012; 51(12R): 125203-9. 
5. Moriguchi Y, Tateishi K, Ando W, Shimomura K, Yonetani Y, Tanaka Y, Kita K, Hart DA, Gobbi A, Shino K, Yoshikawa H, Nakamura N. Repair of meniscal lesions using a scaffold-free tissue-engineered construct derived from allogenic synovial MSCs in a miniature swine model. Biomaterials. 2013 Mar; 34(9): 2185-93. 
6. Shimomura K, Moriguchi Y, Murawski CD, Yoshikawa H, Nakamura N. Osteochondral tissue engineering with biphasic scaffold: Current strategies and techniques. Tissue Eng Part B Rev. 2014 Oct; 20(5): 468-76. 
7. Shimomura K, Moriguchi Y, Ando W, Nansai R, Fujie H, Hart DA, Gobbi A, Kita K, Horibe S, Shino K, Yoshikawa H, Nakamura N. Osteochondral repair using a scaffold-free tissue engineered construct derived from synovial mesenchymal stem cells and a hydroxyapatite-based artificial bone. Tissue Eng Part A. 2014 Sep; 20 (17-18): 2291-304. 
8. Shimomura K, Kanamoto T, Kita K, Akamine Y, Nakamura N, Mae T, Yoshikawa H, Nakata K. Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α. Bone and Joint Research. 2014 Sep; 3(9): 280-8. 
9. Shimomura K, Ando W, Moriguchi Y, Sugita N, Yasui Y, Koizumi K, Fujie H, Hart DA, Yoshikawa H, Nakamura N. Next generation MSC-based cartilage repair using scaffold-free tissue engineered constructs generated with synovial mesenchymal stem cells. Cartilage. 2015 Apr; 6(Suppl 2): 13S–29S. 
10. Shimomura K, Bean AC, Lin H, Nakamura N, Tuan RS. In vitro repair of meniscal radial tear using aligned electrospun nanofibrous scaffold. Tissue Eng Part A. 2015 Jul; 21(13-14): 2066-75. 
11. Scotti C, Gobbi A, Karnatzikos G, Martin I, Shimomura K, Lane JG, Peretti GM, Nakamura N. Cartilage repair in the inflamed joint: considerations for biological augmentation towards tissue regeneration. Tissue Eng Part B Rev. 2016 Apr; 22(2): 149-59. 
12. Fujie H, Nansai R, Ando W, Shimomura K, Moriguchi Y, Hart DA, Nakamura N. Zone-specific integrated cartilage repair using a scaffold-free tissue engineered construct derived from allogenic synovial mesenchymal stem cells: Biomechanical and histological assessments. Journal of Biomechanics. 2015 Nov 26; 48(15): 4101-8. 
13. Yasui Y, Chijimatsu R, Hart DA, Koizumi K, Sugita N, Shimomura K, Myoui A, Yoshikawa H, Nakamura N. Preparation of scaffold-free tissue engineered constructs derived from human synovial mesenchymal stem cells under low oxygen tension enhances their chondrogenic differentiation capacity. Tissue Eng Part A. 2016 Mar; 22(5-6): 490-500. 
14. Yasui Y, Ando W, Shimomura K, Koizumi K, Chijimatsu R, Hamamoto S, Kobayashi M, Yoshikawa H, Nakamura N. Scaffold-free, stem cell-based cartilage repair. Journal of Clinical Orthopaedics and Trauma. 2016 Jul-Sep; 7(3): 157-63. 
15. Shimomura K, Moriguchi Y, Nansai R, Fujie H, Ando W, Horibe S, Hart DA, Gobbi A, Yoshikawa H, Nakamura N. Comparison of 2 different formulations of artificial bone for a hybrid implant with a tissue-engineered construct derived from synovial mesenchymal stem cells. A study using a rabbit osteochondral defect model. Am J Sports Med. 2017 Mar; 45(3): 666-675. 
16. Shimomura K, Rothrauff BB, Tuan RS. Region-specific effect of decellularized meniscus extracellular matrix on mesenchymal stem cell-based meniscus tissue engineering. Am J Sports Med. 2017 Mar; 45(3): 604-611. 
17. Rothrauff BB, Shimomura K, Gottardi R, Alexander PG, Tuan RS. Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. Acta Biomaterialia. 2017 Feb; 49: 140-151. 
18. Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimomura K, Hart DA, Yoshikawa H, Nakamura N. Characterization of mesenchymal stem cell-like cells derived from human iPSCs via neural crest development, and their application for osteochondral repair. Stem Cells Int. 2017; 2017: 1960965.
19. Ikeda Y, Sakaue M, Chijimatsu R, Hart DA, Otsubo H, Shimomura K, Madry H, Suzuki T, Yoshikawa H, Yamashita T, Nakamura N. IGF-1 gene transfer to human synovial MSCs promotes their chondrogenic differentiation potential without induction of the hypertrophic phenotype. Stem Cells Int. 2017; 2017: 5804147. 
20. Yasui Y, Hart DA, Sugita N, Chijimatsu R, Koizumi K, Ando W, Moriguchi Y, Shimomura K, Myoui A, Yoshikawa H, Nakamura N. Time-Dependent Recovery of Human Synovial Membrane Mesenchymal Stem Cell Function After High-Dose Steroid Therapy: Case Report and Laboratory Study. Am J Sports Med. 2018 Mar; 46(3): 695-701. 
21. Yokoi H, Mae T, Iuchi R, Take Y, Tachibana Y, Shimomura K, Ohori T, Shino K, Yoshikawa H, Nakata K. Novel flat and wide meniscal repair material improves the ultimate load of knot breakage in a porcine trans-capsular meniscal repair model. J Exp Orthop. 2017 Dec 19; 4(1): 41. 
22. Shimomura K, Ando W, Fujie H, Hart DA, Yoshikawa H, Nakamura N. Scaffold-free tissue engineering for injured joint surface restoration. J Exp Orthop. 2018 Jan 5; 5(1): 2. 
23. Tsujii A, Hiramatsu K, Shimomura K, Kobayashi M, Mera H, Wakitani S, Nakamura N, Horibe S, Mitsuoka T. Long-term results of autologous bone marrow mesenchymal stem cell transplantation for cartilage defects in the patella: Two case reports with more than 18 years of follow-up. J Orthop Sci. 2020 Sep; 25(5): 920-925. 
24. Shimomura K, Yasui Y, Koizumi K, Chijimatsu R, Hart DA, Yonetani Y, Ando W, Sakaue M, Sugita N, Nishii T, Kanamoto T, Moriguchi Y, Horibe S, Yoshikawa H, Nakamura N. First-in-human pilot study of implantation of a scaffold-free tissue-engineered construct generated from autologous synovial mesenchymal stem cells for repair of knee chondral lesions. Am J Sports Med. 2018 Aug; 46(10): 2384-2393. 
25. Fernandes TL, Shimomura K, Asperti A, Pinheiro CCG, Caetano HVA, Oliveira CRGCM, Nakamura N, Hernandez AJ, Bueno DF. Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment. Stem Cell Reviews and Reports. 2018 Oct; 14(5): 734-743. 
26. Shimomura K, Hamamoto S, Hart DA, Yoshikawa H, Nakamura N. Meniscal Repair and Regeneration: Current Strategies and Future Perspectives. Journal of Clinical Orthopaedics and Trauma. 2018 Jul-Sep; 9(3): 247-253. 
27. Fernandes TL, Kimura HA, Pinheiro CCG, Shimomura K, Nakamura N, Ferreira JRM, Gomoll AH, Hernandez AJ, Bueno DF. Human Synovial MSC Good Manufacturing Practices for Articular Cartilage Regeneration. Tissue Eng Part C Methods. 2018 Dec; 24(12): 709-716. 
28. Shimomura K, Rothrauff BB, Hart DA, Hamamoto S, Kobayashi M, Yoshikawa H, Tuan RS, Nakamura N. Enhanced Repair of Meniscal Hoop Structure Injuries Using An Aligned Electrospun Nanofibrous Scaffold Combined with a Mesenchymal Stem Cell-derived Tissue Engineered Construct. Biomaterials. 2019 Feb; 192: 346-354. 
29. Lin H, Beck AM, Shimomura K, Sohn J, Fritch MR, Deng Y, Kilroy EJ, Tang Y, Alexander PG, Tuan RS. Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect. J Tissue Eng Regen Med. 2019 Aug; 13(8): 1418-1429. 
30. Yokota N, Hattori M, Ohtsuru T, Otsuji M, Lyman S, Shimomura K, Nakamura N. Comparative Clinical Outcomes After Intra-articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis. Am J Sports Med. 2019 Sep; 47(11): 2577-2583. 
31. Jacob G, Shimomura K, Krych AJ, Nakamura N. The Meniscus Tear: A Review of Stem Cell Therapies. Cells. 2019 Dec; 9(1): 92 
32. Yokoi H, Take Y, Uchida R, Magome T, Shimomura K, Mae T, Okamoto T, Hanai T, Chong Y, Sato S, Hikida M, Nakata K. Vibration acceleration promotes endochondral formation during fracture healing through cellular chondrogenic differentiation. PLoS One. 2020 Mar; 15(3): e0229127. 
33. Hamamoto S, Chijimatsu R, Shimomura K, Kobayashi M, Jacob G, Yano F, Saito T, Chung UI, Tanaka S, Nakamura N. Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering. J Exp Orthop. 2020 Mar; 7(1): 10. 
34. Uchida R, Jacob G, Shimomura K, Horibe S, Nakamura N. Biological Augmentation of ACL Repair and Reconstruction: Current Status and Future Perspective. Sports Med Arthrosc Rev. 2020 Jun; 28(2): 49-55. 
35. Hevesi M, Jacob G, Shimomura K, Ando W, Nakamura N, Krych AJ. Current hip cartilage regeneration/repair modalities: a scoping review of biologics and surgery. Int Orthop. 2021 Feb; 45(2): 319-333.  
36. Jacob G, Shimomura K, Nakamura N. Osteochondral Injury, Management and Tissue Engineering Approaches. Front Cell Dev Biol. 2020 Nov; 8: 580868. 
37. Kobayashi M, Chijimatsu R, Hart DA, Hamamoto S, Jacob G, Yano F, Saito T, Shimomura K, Ando W, Chung UI, Tanaka S, Yoshikawa H, Nakamura N. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021 Feb; 15(2): 103-115. 
38. Hanai H, Jacob G, Nakagawa S, Tuan RS, Nakamura N, Shimomura K (Corresponding Author). Potential of soluble decellularized extracellular matrix for musculoskeletal tissue engineering - comparison of various mesenchymal tissues -. Front Cell Dev Biol. 2020 Nov; 8: 581972. 
39. Shimomura K, Hamada H, Hart DA, Ando W, Nishii T, Trattnig S, Nehrer S, Nakamura N. Histological Analysis of Cartilage Defects Repaired with an Autologous Human Stem-cell Construct 48 Weeks Post-Implantation Reveals Structural Details not Detected by T2 Mapping MRI. Cartilage. 2021 Dec; 13 (Suppl 1): 694S-706S. 
40. Morimoto S, Iseki T, Nakayama H, Shimomura K, Nishikawa T, Nakamura N, Tachibana T. Return to the original sport at only 3 months after an Achilles tendon rupture by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and excessively early rehabilitation after operative treatment in a male basketball player: A case report. Regen Ther. 2021 May; 18: 112-116. 
41. Mae T, Shimomura K, Ohori T, Hirose T, Taketomi S, Suzuki T, Nakata K. Suture Slippage During Anterior Cruciate Ligament Graft Passage is Significantly Lower Using a Krackow Suture. Arthrosc Sports Med Rehabil. 2021 Aug; 3(5): e1337-e1341. 
42. Kinugasa K, Shimomura K, Tachibana Y, Hiramatsu K, Horibe S, Shino K, Tanaka Y. Posterior Ankle Impingement Caused by Hyaline-like Cartilage Generation in Ballet Dancers -A Report of 2 Cases. J Foot Ankle Surg. 2022 Jul-Aug; 61(4): e9-e14. 
43. Jacob G, Shimomura K, Yogesh K, Nakamura N. Tissue Wrapping Augmentation for Anterior Cruciate Ligament Reconstruction: A Review of Clinical Literature. Biologic Orthopedics Journal. 2021; 3(SP2): e1-e6. 
44. Yokota N, Lyman S, Hanai H, Shimomura K, Ando W, Nakamura N. Clinical Safety and Effectiveness of Adipose-Derived Stromal Cell vs Stromal Vascular Fraction Injection for Treatment of Knee Osteoarthritis: 2 Year Results of Parallel Single-Arm Trials. Am J Sports Med. 2022 Aug; 50(10): 2659-2668. 
45. Tanaka A, Tsujii A, Shimomura K, Yonetani Y, Hamada M. Two uncommon complications related to suture knots after meniscal all-inside suture repair: A case report. JBJS Case Connect. 2022 Aug; 12(3). 
46. Fernandes TL, Bueno DF, Shimomura K, Shao Z, Gomoll AH. Editorial: Tissue Engineering and Cell Therapy for Cartilage Restoration. Front Cell Dev Biol. 2022 Jul; 10: 947588. 
47. Shimomura K, Jacob G, Hanai H, Nakamura. N. Utilization of Orthobiologic Augmentation for Meniscal Repairs: Current Concepts and Future Perspectives. Journal of Cartilage & Joint Preservation 2022 (in press) 
 
・英文著書
1.Nakamura N, Ando W, Tateishi K, Fujie H, Hart DA, Shimomura K, Kanamoto T, Kohda H, Nakata K, Yoshikawa H, Shino K. Scaffold-free tissue engineered construct (TEC) derived from synovial mesenchymal stem cells: Characterization and demonstration of efficacy to cartilage repair in a large animal model. Sports Injury. 2011: 751-763.
2.Shimomura K, Ando W Yoshikawa H, Nakamura N. Scaffold-free mesenchymal stem cells-based implant to repair three dimensional chondral lesion. The ESSKA Book “Techniques in Cartilage Repair Surgery” Chapter 16: 187-203 (Springer; 2014 edition)
3.Shimomura K, Moriguchi Y, Sugita N, Koizumi K, Yasui Y, Yoshikawa H, Nakamura N. Current strategies in osteochondral repair with biomaterial scaffold. Musculoskeletal Research and Basic Science Chapter 23: 387-403 (Springer; 2016 edition) 
4.Koizumi K, Shimomura K, Yoshikawa H, Nakamura N. Cells and growth factors. ICRS CartilagE-Book Chapter 19: 315-326 (CIC Edizioni Internazionali; 2015 edition)
5.Shimomura K, Ando W, Fujie H, Hart DA, Yoshikawa H, Nakamura N. Scaffold-free stem cell-based tissue engineering to repair cartilage and its potential application to other musculoskeletal tissues. Bio-Orthopaedics: A New Approach Chapter 43: 537-551 (Springer; 2017 edition)
6.Shimomura K, Fujie H, Hart DA, Yoshikawa H, Nakamura N. Osteochondral repair using a hybrid implant composed of stem cells and biomaterial. Bio-Orthopaedics: A New Approach Chapter 53: 671-682 (Springer; 2017 edition)
7.Jacob G, Shimomura K, Nakamura N. Role of MSCs in Symptomatic Cartilage Defects. ISAKOS/ICRS Book “Cartilage Injury of the Knee” Chapter 20: 233-241 (Springer; 2021 edition)
8.Jacob G, Shimomura K, Hart DA, Nakamura N. The Current Role of Stem Cell Therapy and iPS Cells. ISAKOS/ICRS Book “Early Osteoarthritis” Chapter 15: 207-219 (Springer; 2022 edition)
9.Jacob G, Shimomura K, Hart DA, Nakamura N. Meniscus Injury and Early Osteoarthritis. ISAKOS/ICRS Book “Early Osteoarthritis” Chapter 19: 259-269 (Springer; 2022 edition)
10.Jacob G, Shimomura K, Hart DA, Fujie H, Nakamura N. Mechanical and Biologic Properties of Articular Cartilage Repair Biomaterials. ISAKOS Book “Orthopaedic Biomechanics in Sports Medicine” Chapter 5: 57-71 (Springer; 2021 edition)
11.Iseki T, Rothrauff BB, Shimomura K, Nakamura N. Biomechanics of Cartilage Repair. ISAKOS Book “Orthopaedic Biomechanics in Sports Medicine” Chapter 33: 431-438 (Springer; 2021 edition)
12.Jacob G, Shimomura K, Ando W, Hart DA, Nakamura N. Biphasic Osteochondral Restoration Techniques Using Synovial Stem Cells and Artificial Bone. ISAKOS Book “Joint Function Preservation” Chapter 20: 229-235 (Springer; 2022 edition)
13.Shimomura K, Hart DA, Ando W, Nakamura N. Clinical Application of Scaffold-Free Tissue-Engineered Construct Derived from Synovial Stem Cells. ISAKOS Book “Advances in Knee Ligament and Knee Preservation Surgery” Chapter 35: 415-423 (Springer; 2022 edition)
14.Ando W, Wolfe I, Shimomura K, Lyman S, Yokota N, Nakamura N. Current Introduction of the Biological Agent Derived from Adipose Tissue to the Treatment of Knee Osteoarthritis. ISAKOS Book “Advances in Knee Ligament and Knee Preservation Surgery” Chapter 37: 437-450 (Springer; 2022 edition)
15.Shimomura K, Hart DA, Nakamura N. Meniscal Lesions: Cell Therapy. ISAKOS/ICRS Book “Orthobiologics: Injectable Therapies for the Musculoskeletal System” Chapter 22: 265-276 (Springer; 2022 edition)
16.Fernandes TL, Shimomura K, Hart DA, Boffa A, Nakamura N. Cartilage Lesions and Osteoarthritis: Cell Therapy. ISAKOS/ICRS Book “Orthobiologics: Injectable Therapies for the Musculoskeletal System” Chapter 25: 301-314 (Springer; 2022 edition)
 
その他、日本論文3編、依頼原稿10編

教育上の能力に関する事項

教育方法の実践例 1.大阪大学整形外科 医学生 教育担当 (2015-2020年)
2.大阪大学整形外科 海外留学医学生 教育担当 (2015-2020年)
3.大阪大学整形外科 留学医師 研究指導 (2016年 ブラジル医師、2018-2019年 インド医師)
作成した教科書、教材 1.現場で必ず役立つ・知っておきたい 通訳者のための医療の知識 第8章 整形外科(保育社)
2.三次元培養における培養手法と周辺技術動向 第5章 培養細胞を用いた技術開発「滑膜由来間葉系幹細胞を用いた軟骨再生への臨床応用」(情報機構)
3.関節・軟骨の再生医療 第5章 自家細胞利用「スキャフォールドフリー滑膜間葉系幹細胞由来三次元人工組織を用いた半月板再生」(シーエムシー出版)
4.ビジュアル・サージカルテクニック 膝関節鏡視下手術 Chapter 4 診断:軟骨損傷の評価(文光堂)
実務の経験を有する
者についての特記事項
・大阪大学医療通訳養成コース「整形外科領域の基礎知識」講義
・ 大阪大学大学院工学研究科バイオマテリアル化学「軟骨・半月板再生」講義
・ 国際学会シンポジウム・招待講演 3講演(2023年3月現在)
・ 国内学会シンポジウム・招待講演 14演題(2023年3月現在)
その他
科研費:
2015年 研究活動スタート支援
2016-2019年 若手研究(A)
2020-2022年 基盤研究(C)
2023-2025年 基盤研究(C)
 
受賞歴:
2010年 International Cartilage Repair Society Award “Certificate of Merit”
2010年 スポーツ傷害症例検討会奨励賞 “Person of the year”
2015年 ⽇本関節鏡・膝・スホーツ整形外科学会 “Outstanding Young Investigator Award”
2019年 ⼤阪⼤学医学部附属病院 特定臨床研究奨励賞 最優秀論⽂賞
2021年 第26回 ⽇本軟⾻代謝学会賞
2022年 International Cartilage Regeneration & Joint Preservation Society “Magna Cum Laude (最優秀演題賞)”
2023年 日本再生医療学会 “The TreeFrog Young Investigators Travel Grant”

職務上の実績に関する事項

2020年10月〜 
日本 Knee Osteotomy and Joint Preservation 研究会 幹事
2021年6月〜 
日本関節鏡・膝・スポーツ整形外科学会 (JOSKAS) 評議員
資格、免許 医師免許
日本整形外科学会 専門医
日本関節鏡・膝・スポーツ整形外科学会 関節鏡技術認定医(膝)
日本再生医療学会 再生医療認定医
難病指定医
特許等 -
実務の経験を有する者についての特記事項 2013年9月〜 
Member of Standing Committee, International Cartilage Regeneration & Joint Preservation Society (ICRS)
(2016/9〜2019/9 Deputy Chair of Standing Committee)
2020年10月〜 
日本 Knee Osteotomy and Joint Preservation 研究会 幹事
2021年6月〜 
日本関節鏡・膝・スポーツ整形外科学会 (JOSKAS) 評議員
その他 -

教員一覧へ戻る

- KANSAI UNIVERSITY OF WELFARE SCIENCES -
(学校法人 玉手山学園)

〒582-0026 大阪府柏原市旭ケ丘3丁目11-1

072-978-0088